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 Formulary Chapter 11: Eye - Full Chapter
Notes:

Preservative Free Eye Drops
Microbial contamination of multidose bottles of eye drops can cause eye infections that may lead to damage of the eye and in extreme cases loss of sight. To minimise the risk, multidose bottles of eye drops contain an antimicrobial preservative such as benzalkonium chloride. The preservatives used in eye drops are normally well tolerated, but they are not completely harmless. They can cause irritation and damage to the corneal epithelium. This risk is understood to be greater in patients with pre-existing damage to the ocular surface and where large quantities of preservative containing eye drops are applied repeatedly over a prolonged period (e.g. if applied more than 4 to 6 times daily for several weeks/ months).
To avoid these problems the use of preservative-free eye drops is recommended in:
 Patients who have experienced hypersensitivity reactions or irritation due to preservatives in eye drops.
 Patients who have received corneal grafts.
 Patients with conditions where there is already damage to the ocular surface as a result of disease or trauma, such as dry eye, blepharitis, ocular burns etc.
Treatment with preservative-free eye drops will usually be initiated by an ophthalmologist.

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 Details...
11.08.01  Expand sub section  Tear deficiency, ocular lubricants, and astringents
Hypromellose
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First Choice
Green
  • 0.3% eye drops
  • 0.3% preservative-free eye drops:
    • 1st line Tear-Lac®;
    • 2nd line PF Drops® 
      • treatment to be initiated on the advice of ophthalmologist only
 
Artificial Tears Minims
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Formulary
Green

Hydroxyethylcellulose Artifical Tears Minims 4.4mg per mL Minims Eye Drops

 
 
Xailin Night
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Formulary
Green

White soft paraffin and mineral oil

 
 
Acetylcysteine 5% eye drops and preservative free eye drops
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Alternatives
Green plus
 
 
Acetylcysteine 5% with Hypromellose 0.35% (Ilube)
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Alternatives
Green

Eye drops: acetylcysteine 5%, hypromellose 0.35% (Ilube®)

 
 
Balanced Salt Solution
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Alternatives
Red
  • Sterile solution containing sodium chloride 0.64%, sodium acetate 0.39%, sodium citrate 0.17%, calcium chloride 0.048%, magnesium chloride 0.03%, potassium chloride 0.075% in 15ml bottles and 500ml bags.
  • For intra-ocular or topical irrigation during surgical procedures.
 
 
Carbomer 980 eye drops
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Alternatives
Green
  • Viscotears® eye drops
  • GelTears® single unit dose eye drops
 
 
Carmellose sodium
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Alternatives
Green
  • 0.5% and 1% eye drops.
 
 
Duolube® eye ointment
(Lanolin and preservative free)
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Alternatives

UNDER REVIEW

    • Please note
      The brand name will soon change to Sooth Night-time and Duolube will be unable to be ordered

 

 
 
Hylo Night®
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Alternatives
Green
  • Eye ointment (containing retinol palmitate (vitamin A) 250iu/g, white soft paraffin, light liquid paraffin, liquid paraffin and wool fat)
 
 
Sodium Chloride
Alternatives
Green
  • 0.9% eye drops and single dose unit eye drops.
  • 5% eye drops and preservative-free eye drops.
  • 5% eye ointment unlicensedunlicensed.
 
 
Sodium Hyaluronate
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Alternatives
Green
  • 0.1% eye drops & preservative-free eye drops
  • 0.2% eye drops & preservative-free eye drops
  • 0.4% unit dose vials (Clinitas) & 0.4% preservative-free eye drops (Clinitas Multi) 
 
 
Systane®
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Alternatives
Green
  • 10ml multidose bottles 0.8ml preservative-free vials Contains hydroxypropyl guar, polyethylene glycol 400, propylene glycol (and other ingredients).
  • Long-acting ocular lubricant used for the treatment of dry eye syndrome. Liquid formulation which turns into a gel on contact with eyes providing fast and long lasting relief. The multidose bottle may be used for up to six months after opening in primary care. In contact lens wearers, Systane should be applied before inserting lenses and after removal to extend comfortable wearing times.
 
 
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Key
note Notes
Section Title Section Title (top level)
Section Title Section Title (sub level)
First Choice Item First Choice item
Non Formulary Item Non Formulary section
Restricted Drug
Restricted Drug
Unlicensed Drug
Unlicensed
Track Changes
Display tracking information
click to search medicines.org.uk
Link to adult BNF
click to search medicines.org.uk
Link to children's BNF
click to search medicines.org.uk
Link to SPCs
Cytotoxic Drug
Cytotoxic Drug
CD
Controlled Drug
High Cost Medicine
High Cost Medicine
NHSE
NHS England
Homecare
Homecare
CCG
CCG

Traffic Light Status Information

Status Description

Red

Drugs for hospital use only. The responsibility for initiation and monitoring treatment should rest with an appropriate hospital clinician and the drug should be supplied through the hospital throughout the duration of treatment. In some very exceptional circumstances (e.g. due to distance from the hospital, storage, supply or mobility/transport problems) it may be appropriate for the GP to be asked to prescribe a Red drug. This should be negotiated on an individual patient basis and should only be done with the GP’s prior informed agreement where the roles of the GP and hospital services are clearly defined and agreed. The GP should not feel under pressure to prescribe in these circumstances. For all RED drugs automatically added to the formulary in response to a positive NICE TA: Prescribers need to ensure that local Trust new drug governance procedures and pharmacy processes are followed before any prescribing.  

Amber

Drugs initiated by hospital specialist, but where continuing treatment by GPs may be appropriate under a shared care arrangement. The specialist should send the GP a copy of the shared care agreement to sign. The GP should sign the shared care agreement, or indicate they do not want to be part of such an agreement, and return a copy back to the specialist. Shared care guidelines are available or are being developed for most of the drugs listed as Amber. If no shared care guideline is available, the hospital specialist should provide the patient’s GP with sufficient information and support to allow treatment to be continued and managed safely in primary care.  

Green plus

Drugs normally recommended or initiated by a specialist (hospital or GP with an extended role https://www.rcgp.org.uk/gpwer), but can be safely maintained in primary care with very little or no monitoring required. In some cases there may be a further restriction for use outlined - these will be defined in each case. Provision of additional information, or an information leaflet, may be appropriate in some cases to facilitate continuing treatment by GPs.  

Green

Drugs where prescribing by GPs is appropriate. Can be initiated and prescribed in all care settings, and if appropriate, discontinued without recourse to secondary care.  

Black

NOT APPROVED: Drugs that have been considered by NTAG or the NENC ICB Medicines Subcommittee (or other approved body) and are not approved for prescribing within the North East and North Cumbria.   

Brown

UNDER REVIEW: drugs whose current formulary status or RAG status is currently under review.  

Not Recomended

NOT REVIEWED: Drugs that haven not been reviewed yet. This usually means that an application is in progress. These drugs are not normally considered appropriate for prescribing in the North East and North Cumbria until such time that a decision is taken on their formulary status.  

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