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Area Prescribing Committee Formulary  
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 Formulary Chapter 5: Infections - Full Chapter
05.01  Antibacterial drugs
05.01  Table 1. Summary of antibacterial therapy
05.01  Table 2. Summary of antibacterial prophylaxis
05.01.01  Penicillins
05.01.01.01  Benzylpenicillin and phenoxymethylpenicillin to top
Benzylpenicillin
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Green
 
   
Phenoxymethylpenicillin
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Formulary
Green
 
   
Benzylpenicillin Benzathine
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Unlicensed Drug Unlicensed
Red
 
   
Procaine Penicillin
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Unlicensed Drug Unlicensed
Red
 
   
05.01.01.02  Penicillinase-resistant penicillins
Flucloxacillin
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Green
 
   
Temocillin
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Red
  • Restricted for use on microbiology/infectious diseases advice, or as agreed in Trust Guidelines.
 
   
05.01.01.03  Broad-spectrum penicillins
Amoxicillin
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Green
 
   
Co-Amoxiclav
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Green
 
   
05.01.01.04  Antipseudomonal penicillins
Piperacillin and Tazobactam
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Formulary
Red
  • Restricted for use on microbiology/infectious diseases advice, or as agreed in Trust Guidelines.
 
   
05.01.01.05  Mecillinams
Pivmecillinam
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Formulary
Green plus
 
   
05.01.02  Cephalosporins, carbapenems and other beta-lactams to top
05.01.02  Cephalosporins
05.01.02  Other beta-lactam antibiotics
05.01.02.01  Cephalosporins
Cefalexin
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Green
 
   
Cefixime
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Formulary
Green
  • Restricted for use on microbiology/infectious diseases advice, or as agreed in Trust Guidelines.
  • 200mg tablets
  • 100mg in 5ml paediatric suspension: also approved for the prevention of irinotecan induced diarrhoea, specialist use only Red Traffic Light.
 
   
Cefotaxime
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Red
  • Restricted for use on microbiology/infectious diseases advice, or as agreed in Trust Guidelines.
 
   
Ceftaroline
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Formulary
Red
  • Restricted for use on microbiology/infectious diseases advice, or as agreed in Trust Guidelines.
 
   
Ceftazidime
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Red
 
   
Ceftobiprole
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Formulary
Red
  • Approved for the treatment of hospital acquired pneumonia and other infections on the advice of microbiology/infectious disease physicans.
 
   
Ceftolozane & tazobactam
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Formulary
Red
  • Approved for use in multiple antibiotic resistant strains of enterobacteriaceae, pseudomonas and acinetobacters on the advice of microbiology/infectious disease physicians.
 
   
Ceftriaxone
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Formulary
  • Restricted for use on microbiology/infectious diseases advice, or as agreed in Trust Guidelines. Red Traffic Light
  • Approved for use in primary care (i.e. care homes) to treat patients with conditions such as UTIs and pneumonia, at risk of sepsis in line with local guidance and microbiology input Green Traffic Light
 
   
Cefuroxime
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Formulary
Red
 
   
Ceftazadime / avibactam (Zavicefta ®)
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Formulary
Red
  • 2.5g injection
  • Approved for use only on the advice of Microbiology/Infectious Diseases for the treatment of infections with carbapenemase-producing organisms for which treatment options are very limited, toxic and not particularly effective.
 
   
05.01.02.02  Carbapenems
Ertapenem
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Red
 
   
Meropenem
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Red
  • Restricted for use on microbiology/infectious diseases advice, or as agreed in Trust Guidelines.
 
   
Doripenem 500mg injection
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Unlicensed Drug Unlicensed
Red
  • For use as a 2nd line alternative to meropenem in patients known to be infected with organisms resistant to meropenem, or with those organisms with raised MICs to meropenem. Should only be on the advice of microbiology or infectious disease consultants.
 
   
05.01.02.03  Other beta-lactam antibiotics to top
Aztreonam
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Formulary
Red
  • Restricted for use on microbiology/infectious diseases advice, or as agreed in Trust Guidelines.
 
   
Aztreonam nebuliser solution (Cayston®)
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Formulary
Red
High Cost Medicine
  • To be used in accordance with NHS England Commissioning Policy   
 
Link  Clinical Commissioning Policy: Inhaled Therapy for Adults and Children with Cystic Fibrosis
   
05.01.03  Tetracyclines
Oxytetracycline
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Green
 
   
Doxycycline
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Green
 
   
Lymecycline
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Formulary
Green
 
   
Minocycline
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Formulary
Green
 
   
Demeclocycline
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Restricted Drug Restricted
Green plus
  • For the treatment of inappropriate antidiuretic hormone secretion. Treatment is initiated by specialists only.
 
   
05.01.03  Tigecycline
Tigecycline
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Formulary
Red
 
   
05.01.04  Aminoglycosides
Amikacin
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Formulary
Red
  • Restricted for use on microbiology/infectious diseases advice, or as agreed in Trust Guidelines.
 
   
Gentamicin
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Formulary
Red
  • 80mg in 2ml & 20mg in 2ml IV/IM injections
  • 5mg in 1ml intrathecal injection
  • bone cement & beads (for use in orthopaedic surgery) unlicensedunlicensed.
 
   
Neomycin
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Formulary
Red
  • 500mg tablets
  • 1g in 10ml syrup unlicensedunlicensed.
 
   
Tobramycin
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Formulary
Red
High Cost Medicine
  • Restricted for use on microbiology/infectious diseases advice, or as agreed in Trust Guidelines.
    • 80mg in 2ml & 240mg in 6ml injections.
    • 300mg in 4ml (Bramitob®).
    • 300mg in 5ml (Tobi®).
    • TOBI Podhaler.

  • Inhaled preparations to be used for treatment of Cystic Fibrosis in accordance with NHS England Commissioning Policy/NICE Guidance.   
 
Link  Clinical Commissioning Policy: Inhaled Therapy for Adults and Children with Cystic Fibrosis
Link  TA276:Colistimethate sodium and tobramycin dry powders for inhalation for treating pseudomonas lung infection in cystic fibrosis
   
Gentamicin
(Nebulised)
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Unlicensed Drug Unlicensed
Green plus
  • For long term therapy in non-cystic fibrosis bronchiectasis usually in patients having > 3 exacerbations per annum with an organism identified as being sensitive to gentamicin.
 
Link  Nebulised Gentamicin Information for Treatment of Adults in Primary Care
   
Spectinomycin
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Unlicensed Drug Unlicensed
Red
  • Only approved for the treatment of gonorrhoea in adults.

 

 
   
05.01.05  Macrolides
Clarithromycin
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First Choice
Green
 
Erythromycin
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First Choice
Green
 
Azithromycin
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Alternatives
Green
 
   
05.01.06  Clindamycin to top
Clindamycin
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Formulary
Green
  • 150mg capsules.
  • 75mg in 5ml suspension unlicensedunlicensed.
  • 300mg in 2ml & 600mg in 4ml injections.
 
   
05.01.07  Some other antibacterials
Dalbavancin (Xydalba ®)
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Formulary
Red
  • 500mg injection
    • approved for the treatment of significant deep soft tissue infections such as joint, discitis and spinal infection, on the advice of infectious disease physicians or microbiology.

 
   
05.01.07  Chloramphenicol
Chloramphenicol
(Systemic)
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Formulary
Red
  • Restricted for use on microbiology/infectious diseases advice, or as agreed in Trust Guidelines.
 
   
05.01.07  Fosfomycin
Fosfomycin
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Formulary
  • 500mg capsules unlicensedunlicensed Red Traffic Light
  • 4g injections Red Traffic Light
  • 3g sachets: sachets can be initiated in primary care for the treatment of UTIs caused by multi-resistant organisms following advice from microbiology only. Most cost effective option to be used Green Traffic Light
 
   
05.01.07  Fusidic acid
Sodium fusidate
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Formulary
Green
 
   
05.01.07  Vancomycin and teicoplanin to top
Teicoplanin
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Formulary
Red
  • Restricted for use on microbiology/infectious diseases advice, or as agreed in Trust Guidelines.
 
   
Vancomycin
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Formulary
Green plus
  • Restricted for use on microbiology/infectious diseases advice, or as agreed in Trust Guidelines.
    • 125mg capsules Green Traffic Light.
    • 500mg and 1g injections Red Traffic Light
    • 20mg in 4ml intrathecal injection unlicensedunlicensed Red Traffic Light.

 
   
05.01.07  Daptomycin
Daptomycin
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Formulary
Red
 
   
05.01.07  Linezolid
Linezolid
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Formulary
Red
  • Restricted for use on microbiology/infectious diseases advice, or as agreed in Trust Guidelines.
 
   
05.01.07  Quinupristin and dalfopristin
05.01.07  Polymyxins
Colistimethate
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Formulary
Green plus
  • 1 million-unit & 2 million-unit vial for nebulisation/intravenous injection
    • Nebulised therapy for bronchiectasis Green Traffic Light.
    • Nebulised therapy for CF Red Traffic Light.
    • Intravenous therapy Red Traffic Light.
  • Dry powder for inhalation (Colobreath®) Red Traffic Light.
    • To be used for treatment of Cystic Fibrosis in accordance with NHS England Commissioning Policy/NICE Guidance.      
 
Link  Clinical Commissioning Policy: Inhaled Therapy for Adults and Children with Cystic Fibrosis
Link  TA276:Colistimethate sodium and tobramycin dry powders for inhalation for treating pseudomonas lung infection in cystic fibrosis
   
05.01.07  Rifaximin to top
Rifaximin
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Formulary
Green plus
  • 550mg Tablets: Only approved for use in accordance with NICE guidance. 

 

 
Link  TA337: Rifaximin for preventing episodes of overt hepatic encephalopathy
   
05.01.07  Fidaxomicin
Fidaxomicin
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Formulary
Red
High Cost Medicine
  • Approved for third line use in the treatment of C. difficile. To be initiated on the recommendation of a consultant microbiologist.
 
   
05.01.08  Sulphonamides and trimethoprim
Co-trimoxazole
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Formulary
Green
  • 480mg tablets (plain or dispersible), 960mg tablets, 240mg in 5ml & 480mg in 5ml suspensions Green Traffic Light.
  • 480mg in 5ml ampoules for IV infusion Red Traffic Light.    
 
   
Trimethoprim
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Formulary
Green
 
   
05.01.09  Antituberculosis drugs
Ethambutol
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Formulary
Green plus
 
   
Isoniazid
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Formulary
Green plus
  • 50mg & 100mg tablets
  • 50mg in 5ml elixir unlicensedunlicensed
  • 50mg in 2ml injection
 
   
Rifabutin
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Formulary
Green plus
 
   
Rifampicin
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Formulary
Green plus
  • 150mg & 300mg capsules Green Traffic Light
  • 100mg in 5ml syrup Green Traffic Light
  • 600mg injection Red Traffic Light  
 
   
Rifampicin and Isoniazid
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Formulary
Green plus
 
   
Rifampicin and Isoniazid and Pyrazinamide
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Formulary
Green plus
 
   
Bedaquiline
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Formulary
Red
High Cost Medicine
  • To be used in accordance with NHS England Commissioning Policy 
 
Link  Clinical Commissioning Policy: Bedaquiline and Delamanid for defined patients with MDR-TB and XDR-TB
   
Delamanid
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Formulary
Red
High Cost Medicine
  • To be used in accordance with NHS England Commissioning Policy 
 
Link  Clinical Commissioning Policy: Bedaquiline and Delamanid for defined patients with MDR-TB and XDR-TB
   
Pyrazinamide
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Unlicensed Drug Unlicensed
Green plus
 
   
Streptomycin
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Unlicensed Drug Unlicensed
Red
 
   
05.01.10  Antileprotic drugs
Dapsone
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Formulary
Green plus
  • Used in the treatment of leprosy and some skin conditions (e.g. dermatitis herpetiformis, pemphigoid on the advice of dermatologists).
 
   
05.01.11  Metronidazole and tinidazole to top
Metronidazole
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Formulary
Green
  • 200mg & 400mg tablets Green Traffic Light.
  • 200mg in 5ml suspension Green Traffic Light.
  • 500mg & 1g suppositories Green Traffic Light.
  • 50mg in 10ml injection & 500mg in 100ml IV infusion Red Traffic Light.
 
   
05.01.12  Quinolones
Ciprofloxacin
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First Choice
Green
  • 250mg, 500mg & 750mg tablets
  • 250mg in 5ml suspension
  • 100mg & 200mg, 400mg intravenous infusions Red Traffic Light.
 
Moxifloxacin
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Alternatives
Green
 
   
Ofloxacin
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Alternatives
Green
  • For use in the treatment of pelvic inflammatory disease and chlamydia genital tract infections in accordance with local primary care guidelines.
 
   
Levofloxacin
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Alternatives
Green
  • 250mg & 500mg tablets Green
  • 5mg/1ml eye dropsGreen
  • 500mg/100ml infusion Red
  • 240mg/2.4ml nebuliser solution in line with NHS England Commissioning Policy Red
 
   
05.01.13  Urinary-tract infections
Nitrofurantoin
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Formulary
Green
  • Note: Liquid presentations of nitrofurantoin are very expensive compared to
    other solid dosage formulation. Please consider whether capsules can be used.
 
   
Methenamine Hippurate
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Formulary
Green
  • Approved as second line agent for prophylaxis in patients with recurrent UTI’s who have failed long-term antibiotic prophylaxis, have contraindications to antibiotics or breakthrough infection with resistant organisms.
 
   
05.02  Antifungal drugs
05.02  Treatment of fungal infections
05.02  Drugs used in fungal infections to top
05.02.01  Triazole antifungals
Fluconazole
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Formulary
Green
 
   
Itraconazole
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Formulary
Green
  • 100mg capsules Green Traffic Light.
  • 50mg in 5ml oral solution Green Traffic Light
  • 250mg in 25ml injection for IV infusion Red Traffic Light
 
   
Isavuconazole (Cresemba®)
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Formulary
Red
High Cost Medicine
  • Approved for use in line with licensed indications and specifically in solid organ transplant and bone marrow transplant recipients.
 
   
Posaconazole  (Noxafil®)
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Formulary
Red
High Cost Medicine
  • Approved for the prevention of invasive fungal infection in immunocompromised patients in whom there is a specific risk of aspergillus infection or where fluconazole and itraconazole are not tolerated or are unlikely to be sufficiently effective (largely for secondary prevention).
  • Approved for patients with invasive fungal infections that are not responding to other treatments or where they are not tolerated (largely in place of liposomal amphotericin/ voriconazole).
 
   
Voriconazole
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Formulary
Red
 
   
05.02.02  Imidazole antifungals
05.02.03  Polyene antifungals
Nystatin
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Formulary
Green
  • 100,000 units/ml suspension Green Traffic Light.
  • 100,000 unit pessaries unlicensedunlicensed Red Traffic Light
    • Second line treatment for vaginal non albicans infection, for patients who have not responded to standard treatments such as azoles. Prescribing is restricted to the GUM clinics.

 
   
Amphotericin
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Formulary
Red
High Cost Medicine
  • 50mg injection (Fungizone®)
  • 50mg liposomal injection (Ambisome®)
 
   
05.02.04  Echinocandin antifungals
Anidulafungin
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Formulary
Red
High Cost Medicine
 
   
Caspofungin
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Formulary
Red
High Cost Medicine
 
   
Micafungin
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Formulary
Red
High Cost Medicine
 
   
05.02.05  Other antifungals to top
Terbinafine
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Formulary
Green
 
   
Griseofulvin
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Formulary
Green
  • For very limited use where terbinafine is contraindicated.
 
   
Flucytosine
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Formulary
Red
  • 500mg tabletsunlicensedunlicensed.
  • 2.5g in 250ml IV infusion.
 
   
05.03  Antiviral drugs
05.03.01  HIV infection
05.03.01  Nucleoside reverse transcriptase inhibitors
Abacavir
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Formulary
Red
High Cost Medicine
 
   
Didanosine
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Formulary
Red
High Cost Medicine
 
   
Emtricitabine
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Formulary
Red
High Cost Medicine
 
   
Lamivudine
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Formulary
Red
  • 150 mg and 300 mg tablets
  • 50 mg/5ml oral solution
 
   
Stavudine
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Formulary
Red
High Cost Medicine
 
   
Tenofovir Disoproxil
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Formulary
Red
 
   
Zidovudine
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Formulary
Red
High Cost Medicine
 
   
05.03.01  Protease inhibitors
Saquinavir
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Formulary
Red
High Cost Medicine
 
   
Tipranavir
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Formulary
Red
High Cost Medicine
 
   
Atazanavir
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Formulary
Red
High Cost Medicine
  • For limited use as part of triple therapy where other protease inhibitors are unsuitable
 
   
Atazanavir sulfate and cobicistat
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Formulary
Red
High Cost Medicine

To be used in accordance with NHS England Clinical Commissioning Policy (SSC1614).

 
   
Darunavir
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Formulary
Red
High Cost Medicine
 
   
Darunavir and Cobicistat
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Formulary
Red
High Cost Medicine

To be used in accordance with NHS England Clinical Commissioning Policy (SSC1614).

 
   
Fosamprenavir
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Formulary
Red
High Cost Medicine
 
   
Indinavir
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Formulary
Red
High Cost Medicine
 
   
Nelfinavir
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Formulary
Red
High Cost Medicine
 
   
Ritonavir
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Formulary
Red
High Cost Medicine
 
   
05.03.01  Non-nucleoside reverse transcriptase inhibitors to top
Efavirenz (Sustiva®)
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Formulary
Red
High Cost Medicine
 
   
Etravirine (Intelence®)
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Formulary
Red
High Cost Medicine
 
   
Nevirapine
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Formulary
Red
High Cost Medicine
 
   
Rilpivirine hydrochloride
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Formulary
Red
High Cost Medicine
  • For patients who, due to renal impairment, require reduced doses that are not able to be accommodated by the fixed combination product.
 
   
05.03.01  Other antiretrovirals
Dolutegravir
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Formulary
Red
High Cost Medicine
 
   
Enfuvirtide
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Formulary
Red
High Cost Medicine
 
   
Maraviroc
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Formulary
Red
High Cost Medicine
  • Approved for use in the treatment of patients with HIV infections that are resistant to standard therapy in accordance with British HIV Association and EACS guidelines.
 
   
Raltegravir
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Formulary
Red
High Cost Medicine
  • Approved for use in the treatment of patients with HIV infections that are resistant to standard therapy in accordance with British HIV Association and EACS guidelines.
 
   
05.03.01  Pharmacokinetic enhancers of anti-retrovirals
Cobicistat (Tybost®)
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Formulary
Red
High Cost Medicine
 
Link  Clinical Commissioning Policy F03/P/b: Use of cobicistat as a booster in treatment of HIV positive adults and adolescents
   
05.03.01  Combination Products
Abacavir & Lamivudine
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Formulary
Red
High Cost Medicine
 
   
Abacavir & Lamivudine & Zidovudine
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Formulary
Red
High Cost Medicine
 
   
Abacavir & Lamivudine & Dolutegravir
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
 
   
Tenofovir Disoproxil & Emtricitabine
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Formulary
Red
High Cost Medicine
 
   
Lopinavir and Ritonavir (Kaletra®)
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Formulary
Red
High Cost Medicine
 
   
Tenofovir Disoproxil & Emtricitabine & Rilpivirine
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
 
   
Tenofovir Disproxil & Cobicistat & Elvitegravir & Emtricitabine
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
  • To be used in accordance with NHS England Clinical Commissioning Policy.
 
   
Tenofovir Disproxil & Efavirenz & Emtricitabine
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
 
   
Tenofovir alafenamide & Cobicistat & Emtricitabine & Elvitegravir  (Genvoya®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
  • To be used in accordance with NHS England Clinical Commissioning Policy.
 
   
Tenofovir alafenamide & Emtricitabine
(Descovy®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
  • Film coated tablets containing:
    • emtricitabine 200mg & tenofovir alafenamide (as fumarate) 10mg
    • emtricitabine 200mg & tenofovir alafenamide (as fumarate) 25mg

  • To be used in accordance with NHS England Clinical Commissioning Policy.
 
   
Tenofovir alafenamide & Emtricitabine & Rilpivirine  (Odefsey®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
  • Film coated tablets containing rilpivirine 25mg, emtricitabine 200mg & tenofovir alafenamide (as fumarate) 25mg
  • To be used in accordance with NHS England Clinical Commissioning Policy.
 
   
Zidovudine & Lamivudine
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
 
   
05.03.02  Herpesvirus infections
05.03.02.01  Herpes simplex and varicella-zoster infection to top
Aciclovir
View adult BNF View SPC online View childrens BNF  Track Changes
First Choice
Green
 
Valaciclovir
View adult BNF View SPC online View childrens BNF  Track Changes
Alternatives
Green
 
   
05.03.02.02  Cytomegalovirus infection
Foscarnet Sodium
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
 
   
Ganciclovir
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
 
   
Valganciclovir (Valcyte®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
 
   
Cidofovir infusion
View adult BNF View SPC online View childrens BNF  Track Changes
Restricted Drug Restricted
Red
High Cost Medicine
  • For use in the prevention and treatment of cytomegalovirus infection. 
  • For limited use by ENT Surgeons in the treatment of selected
    patients with respiratory papillomatosis (unlicensedunlicensed)
 
   
05.03.03  Viral hepatitis
05.03.03.01  Chronic hepatitis B
Entecavir
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
 
Link  NICE CG165: Hepatitis B (incorporates TA153)
Link  NICE TA153: Hepatitis B (chronic) - etecavir
   
Lamivudine
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
 
Link  NICE CG165: Chronic Hepatitis B
   
Tenofovir Disproxil (Viread®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
 
Link  NICE CG165: Hepatitis B (incorporates TA153)
Link  NICE TA173: Hepatitis B (chronic) - tenofovir disoproxil
   
05.03.03.02  Chronic hepatitis C
Daclatasvir
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
NHS England
  • Approved for the treatment of chronic hepatitis C in line with NICE and NHS England Commissioning Policy.  
 
Link  NICE TA364: Daclatasvir for treating chronic hepatitis C
   
Dasabuvir (Exviera®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
NHS England
  • Approved for the treatment of chronic hepatitis C in line with NICE and NHS England Commissioning Policy.
 
Link  NICE TA365: Ombitasvir–paritaprevir–ritonavir with or without dasabuvir for treating chronic hepatitis C
   
Elbasvir & grazoprevir (Zepatier®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
NHS England
  • Approved for the treatment of chronic hepatitis C in line with NICE and NHS England Commissioning Policy.
 
Link  NICE TA413: Elbasvir–grazoprevir for treating chronic hepatitis C
   
Glecaprevir & Pibrentasvir (Maviret®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
NHS England
  • Approved for the treatment of chronic hepatitis C in line with NICE and NHS England Commissioning Policy.
 
Link  NICE TA499: Glecaprevir–pibrentasvir for treating chronic hepatitis C
   
Ombitasvir & paritaprevir & ritonavir (Viekirax®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
NHS England
  • Approved for the treatment of chronic hepatitis C in line with NICE and NHS England Commissioning Policy.
 
Link  NICE TA365: Ombitasvir–paritaprevir–ritonavir with or without dasabuvir for treating chronic hepatitis C
   
Ribavirin
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
NHS England
 
Link  NICE TA106: Hepatitis C - peginterferon alfa and ribavirin
Link  NICE TA200: Hepatitis C - peginterferon alfa and ribavirin
Link  NICE TA75: Hepatitis C - pegylated interferons, ribavirin and alfa interferon
   
Sofosbuvir (Sovaldi®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
NHS England
  • Approved for the treatment of chronic hepatitis C in line with NICE and NHS England Commissioning Policy.
 
Link  NICE TA330: Sofosbuvir for treating chronic hepatitis C
   
Sofosbuvir & Ledipasvir  (Harvoni®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
NHS England
  • To be used in accordance with NHS England Commissiong Policy  
 
Link  NICE TAG63: Ledipasvir–sofosbuvir for treating chronic hepatitis C
   
Sofosbuvir & velpatasvir ( Epclusa®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
NHS England
  • Approved for the treatment of chronic hepatitis C in line with NICE and NHS England Commissioning Policy.
 
Link  NICE TA430: Sofosbuvir–velpatasvir for treating chronic hepatitis C
   
Sofosbuvir, Velpatasvir & Voxilaprevir  (Vosevi®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
NHS England
  • Approved for the treatment of chronic hepatitis C in line with NICE and NHS England Commissioning Policy.
 
Link  NICE TA507: Sofosbuvir–velpatasvir–voxilaprevir for treating chronic hepatitis C
   
05.03.04  Influenza to top
Oseltamivir
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green
  • Only approved for use in accordance with NICE guidance. 
 
Link  NICE TA158: Oseltamivir, amantadine (review) and zanamivir for the prophylaxis of influenza
Link  NICE TA168: Amantadine, oseltamivir and zanamivir for the treatment of influenza
   
Zanamivir inhalation (Relenza®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green
  • Only approved for use in accordance with NICE guidance. 
 
Link  NICE TA158: Oseltamivir, amantadine (review) and zanamivir for the prophylaxis of influenza
Link  NICE TA168: Amantadine, oseltamivir and zanamivir for the treatment of influenza
   
05.03.05  Respiratory syncytial virus
Palivizumab
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
  • To be used in accordance with NHS England Commissioning Policy.   
 
   
Ribavirin (Virazole®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
 
   
05.04  Antiprotozoal drugs
05.04.01  Antimalarials
05.04.01  Treatment of malaria
Artesunate
(injection)
View adult BNF View SPC online View childrens BNF  Track Changes
Unlicensed Drug Unlicensed
Red
  • Approved for severe malaria in in line WHO guidance.
 
   
05.04.01  Falciparum malaria (treatment) to top
05.04.01  Benign malarias (treatment)
05.04.01  Prophylaxis against malaria
05.04.01  Specific recommendations
05.04.01  Artemether with lumefabtrine
05.04.01  Chloroquine to top
Chloroquine
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green
  • 200mg tablets (=150mg chloroquine base) Green Traffic Light Not NHS Not NHS. 
  • 68mg in 5ml syrup (=50mg in 5ml chloroquine) Green Traffic Light Not NHS Not NHS
    272.5mg in 5ml injection (=200mg in 5ml chloroquine) unlicensedunlicensed Red Traffic Light.
 
   
05.04.01  Mefloquine
Mefloquine
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green plus

Note: not approved on the NHS for prophylaxis. Not NHS 

 
   
05.04.01  Primaquine
Primaquine
View adult BNF View SPC online View childrens BNF  Track Changes
Unlicensed Drug Unlicensed
Red
 
   
05.04.01  Proguanil
05.04.01  Pyrimethamine
Pyrimethamine (Darprim®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
 
   
05.04.01  Quinine to top
Quinine sulphate
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
 
   
Quinine Dyhydrochloride
View adult BNF View SPC online View childrens BNF  Track Changes
Unlicensed Drug Unlicensed
Red
 
   
05.04.01  Tetracyclines
05.04.02  Amoebicides
Metronidazole
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green
 
   
Diloxanide
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
 
   
05.04.03  Trichomonacides
05.04.04  Antigiardial drugs
Metronidazole
(giardia)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green plus
 
   
Mepacrine Hydrochloride
View adult BNF View SPC online View childrens BNF  Track Changes
Unlicensed Drug Unlicensed
Green plus
 
   
05.04.05  Leishmaniacides to top
Sodium Stibogluconate
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
 
   
05.04.06  Trypanocides
05.04.07  Drugs for toxoplasmosis
05.04.08  Drugs for pneumocystis pneumonia
Co-trimoxazole
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green plus
  • 480mg/5ml injection Red Traffic Light.
 
   
Atovaquone
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
  • Approved for use in patients intolerant of co-trimoxazole
 
   
Pentamidine Isetionate
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
 
   
05.04.08  Treatment
05.04.08  Prophylaxis to top
05.05  Anthelmintics
05.05.01  Drugs for threadworms
Mebendazole
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green
 
   
Piperazine
(With sennosides)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green
 
   
Albendazole
View adult BNF View SPC online View childrens BNF  Track Changes
Unlicensed Drug Unlicensed
Red
 
   
05.05.02  Ascaricides
05.05.03  Drugs for tapeworm infections
05.05.03  Taenicides to top
05.05.03  Hydatid disease
05.05.04  Drugs for hookworms
05.05.05  Schistosomicides
Praziquatel Biltricide
View adult BNF View SPC online View childrens BNF  Track Changes
Unlicensed Drug Unlicensed
Red
 
   
05.05.06  Filaricides
05.05.07  Drugs for cutaneous larva migrans to top
05.05.08  Drugs for strongyloidiasis
 ....
Key
note Notes
Section Title Section Title (top level)
Section Title Section Title (sub level)
First Choice Item First Choice item
Non Formulary Item Non Formulary section
Restricted Drug
Restricted Drug
Unlicensed Drug
Unlicensed
Track Changes
Display tracking information
click to search medicines.org.uk
Link to adult BNF
click to search medicines.org.uk
Link to children's BNF
click to search medicines.org.uk
Link to SPCs
SMC
Scottish Medicines Consortium
Cytotoxic Drug
Cytotoxic Drug
CD
Controlled Drug
High Cost Medicine
High Cost Medicine
Cancer Drugs Fund
Cancer Drugs Fund
NHSE
NHS England
Homecare
Homecare
CCG
CCG

Traffic Light Status Information

Status Description

Red

Drugs for hospital use only. The responsibility for initiation and monitoring treatment should rest with an appropriate hospital clinician and the drug should be supplied through the hospital throughout the duration of treatment. In some very exceptional circumstances (e.g. due to distance from the hospital, storage, supply or mobility/transport problems) it may be appropriate for the GP to be asked to prescribe a Red drug. This should be negotiated on an individual patient basis and should only be done with the GP’s prior informed agreement where the roles of the GP and hospital services are clearly defined and agreed. The GP should not feel under pressure to prescribe in these circumstances.   

Amber

Drugs initiated by hospital specialist, but where continuing treatment by GPs may be appropriate under a shared care arrangement. The specialist should send the GP a copy of the shared care agreement to sign. The GP should sign the shared care agreement, or indicate they do not want to be part of such an agreement, and return a copy back to the specialist. Shared care guidelines are available or are being developed for most of the drugs listed as Amber. If no shared care guideline is available, the hospital specialist should provide the patient’s GP with sufficient information and support to allow treatment to be continued and managed safely in primary care.  

Green plus

Drugs normally recommended or initiated by hospital specialist, but where the provision of an information leaflet may be appropriate to facilitate continuing treatment by GPs. Many of these information sheets are in the process of development.  

Green

Drugs where prescribing by GPs is appropriate. Drugs not classified as Red, Amber or Green Plus (formerly blue in North of Tyne) are generally classified as ‘Green’ by default. The Green drugs listed here include those products normally initiated by hospital specialists where there was a need for discussion and debate as to the category in which they should be placed.  

netFormulary